Abstract:
Calcium phosphate nanoparticles are important for the nano medicine in biomedical. It is
main inorganic component in the human bone and teeth. It has good biodegradability,
biocompatibility and bioactivity. Mainly calcium phosphate nanoparticles (nCaP) are
nontoxic. Therefore it can be used as a drug carrier. Because in different pH areas it can be
controlled the drug release and mainly able to release drug in proper area. Especially this
nanoparticle calcium phosphate used to treat bone cancers. Bone cancer is malignant
tumor. There are different types of bone cancers such as osteosarcoma, Chordoma,
fibrosarcoma, chondrosarcoma….etc. This research was found poly lactic acid (PLA) and
poly lactic-co- glycolic acid (PLGA) microspheres for 3 dimensional (3D) printing and as a
drug carrier respectively. PLA has high molecular mass. Therefore it is difficult to prepare
nanometer scale microsphere from PLA. 3D printing microsphere should be in
micrometer scale and drug loading microsphere should be in nanometer range. Inside this
microsphere have nCaP particles. These nCaP particles in nanometer range and it is the
special material for treatment. This microsphere preparation was checked with nCaP
which prepared in different temperature. The nCaP particles were prepared during one
hour and microsphere samples were prepared during three hours. Micrometer scale
microspheres and nanometer scale microspheres were prepared with magnetic stirring
method and ultrasonic method respectively. There are different methods to prepare nCaP
particles. In here, precipitation method was used to prepare nCaP particles.
Crystalinity of the nCaP particles vary with temperature. Prepared 3D printing
microspheres were in 50μm to 80μm range and nanospheres were in 90nm to 100nm
range. These all nCaP particles and microspheres were characterized by using different
methods and instruments. All characterization methods were given best results about
microspheres and able to use as 3D printing and as drug carrier.
